The great thing about podcasts is that there are many, many to choose from. The bad thing about podcasts is that there are many, many to choose from. That's why it's nice that sites like PodcastAwards.com arise from this mess. They list 50 or so of top podcasts as voted on by people like you and me - on such topics as business, comedy, culture/arts, education, food & drink, gaming, general, gay & lesbian, health & fitness, movies, music, politics, religion, sports, science and travel.
In any case, it is ironic that there's so much interesting podcasting content to choose from, yet it is very, very hard to find things of high quality.